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We know that most cases of narcolepsy are caused by a loss a wake promoting neurotransmitter called hypocretin (aka orexin). We don't know what causes the loss of these neurons but it appears to be secondary to autoimmune destruction. We don't fake ugg boots manchester know what triggers this cell destruction but it is hypothesized that it may be a viral infection.
In dogs, narcolepsy was found to be caused by a genetic mutation, but after years of searching the human genome, researchers could not find a similar genetic cause in humans. There is a blood test called HLA DQB10602, which is usually positive in patients with clear cut narcolepsy with cataplexy but this only shows that the disorder is probably an autoimmune disorder. And many people are positive for this test who never develop narcolepsy. It is not a test fake uggs uk
that is clinically very useful and is generally used only in research.
We have good medications to treat narcolepsy. For daytime sleepiness, we usually use modafinil, which is a wake fake ugg websites
promoting agent that is far gentler with fewer side effects than the traditional amphetamines that were used for years. The newest drug to treat narcolepsy is sodium oxybate, which is a strong sedative that is used to consolidate sleep and help narcoleptic patients achieve more deep sleep. It also can control cataplexy, although how it does this is not fully understood.
I have seen so many narcoleptic patients come to me as complete wrecks because the symptoms can cause such havoc on their personal and professional lives, which in turns leads to depression and despair. But when the patient gets the needed treatment, red fake ugg boots
it is really like he or she is a new person with a new lease on life.
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